Selleck S2061 Lovastatin 50mg

Lovastatin是一种HMG-CoA还原酶抑制剂，无细胞试验中IC50为3.4 nM，用于降胆固醇（降脂药）。

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货品编号：Selleck.S2061

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品牌：Selleck
所属分类：工具酶

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</div>     货品编号：  Selleck.S2061     品牌：  Selleck     品名：  Lovastatin     规格：  <span style="display: inline !important; float: none; background-color: transparent; color: rgb(0, 0, 0); cursor: text; font-family: Arial,Verdana,sans-serif; font-size: 12px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;"> 50mg <span style="display: inline !important; float: none; background-color: transparent; color: rgb(0, 0, 0); cursor: text; font-family: Arial,Verdana,sans-serif; font-size: 12px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;"> <span style="display: inline !important; float: none; background-color: transparent; color: rgb(0, 0, 0); cursor: text; font-family: Arial,Verdana,sans-serif; font-size: 12px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;">     产品描述<span style="display: inline !important; float: none; background-color: transparent; color: rgb(0, 0, 0); cursor: text; font-family: Arial,Verdana,sans-serif; font-size: 12px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;">     Lovastatin是一种HMG-CoA还原酶抑制剂，无细胞试验中IC50为3.4 nM，用于降胆固醇（降脂药）。<span style="display: inline !important; float: none; background-color: transparent; color: rgb(0, 0, 0); cursor: text; font-family: Arial,Verdana,sans-serif; font-size: 12px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;"> <span style="display: inline !important; float: none; background-color: transparent; color: rgb(0, 0, 0); cursor: text; font-family: Arial,Verdana,sans-serif; font-size: 12px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;">     体外研究<span style="display: inline !important; float: none; background-color: transparent; color: rgb(0, 0, 0); cursor: text; font-family: Arial,Verdana,sans-serif; font-size: 12px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;">     在大鼠原代星形胶质细胞中，Lovastatin抑制了LPS-和细胞因子介导的NO产生以及iNOS的表达。在大鼠<span style="display: inline !important; float: none; background-color: transparent; color: rgb(0, 0, 0); cursor: text; font-family: Arial,Verdana,sans-serif; font-size: 12px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;">     原代星形胶质细胞，小胶质细胞和巨噬细胞中，Lovastatin抑制了LPS-诱导的TNF-α，IL-1β和IL-6的表达。[1]<span style="display: inline !important; float: none; background-color: transparent; color: rgb(0, 0, 0); cursor: text; font-family: Arial,Verdana,sans-serif; font-size: 12px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;">     Lovastatin导致超过95％的DNA合成的抑制，这通过[3H]胸苷与DNA的结合测定。Lovastatin使细胞同步在G1，<span style="display: inline !important; float: none; background-color: transparent; color: rgb(0, 0, 0); cursor: text; font-family: Arial,Verdana,sans-serif; font-size: 12px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;">     而不是在细胞周期的G0期。Lovastatin对RAS的依赖性以及RAS无关的细胞系有相似的生长抑制活性。[2] <span style="display: inline !important; float: none; background-color: transparent; color: rgb(0, 0, 0); cursor: text; font-family: Arial,Verdana,sans-serif; font-size: 12px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;">     Lovastatin使载脂蛋白-B的含脂蛋白显著减少，特别是低密度脂蛋白胆固醇，以及血浆甘油三酯erides，以及高<span style="display: inline !important; float: none; background-color: transparent; color: rgb(0, 0, 0); cursor: text; font-family: Arial,Verdana,sans-serif; font-size: 12px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;">     密度脂蛋白胆固醇的少量增加。[3] Lovastatin通过抑制蛋白酶体使细胞停滞，这导致p21和p27蛋白的积累，使<span style="display: inline !important; float: none; background-color: transparent; color: rgb(0, 0, 0); cursor: text; font-family: Arial,Verdana,sans-serif; font-size: 12px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;">     细胞阻滞在G1期。Lovastatin是羟甲基戊二酰基（HMG)-CoA还原酶，是胆固醇合成的限速酶。Lovastatin可用<span style="display: inline !important; float: none; background-color: transparent; color: rgb(0, 0, 0); cursor: text; font-family: Arial,Verdana,sans-serif; font-size: 12px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;">     于阻止培养细胞在细胞周期的G1期，导致细胞周期蛋白依赖性激酶抑制剂（CKIs）p21和p27蛋白的稳定化。[4] <span style="display: inline !important; float: none; background-color: transparent; color: rgb(0, 0, 0); cursor: text; font-family: Arial,Verdana,sans-serif; font-size: 12px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;">     在表达激活p21ras的人膀胱癌T24细胞中，Lovastatin（2-10 mM）使细胞停留在G1期和并延长-或使一小部分细<span style="display: inline !important; float: none; background-color: transparent; color: rgb(0, 0, 0); cursor: text; font-family: Arial,Verdana,sans-serif; font-size: 12px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;">     胞停滞-在细胞周期中的G2期。的G2期。在人膀胱癌T24细胞中，Lovastatin（50 mM）表现细胞毒性。[5]<span style="display: inline !important; float: none; background-color: transparent; color: rgb(0, 0, 0); cursor: text; font-family: Arial,Verdana,sans-serif; font-size: 12px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;"> <span style="display: inline !important; float: none; background-color: transparent; color: rgb(0, 0, 0); cursor: text; font-family: Arial,Verdana,sans-serif; font-size: 12px; font-style: normal; font-variant: normal; font-weight: 400; letter-spacing: normal; orphans: 2; text-align: left; text-decoration: none; text-indent: 0px; text-transform: none; -webkit-text-stroke-width: 0px; white-space: normal; word-spacing: 0px;">

Selleck S2061 Lovastatin 50mg

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