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货品编号： PeproTech.315-02-50
品牌： PeproTech
品名： Murine M-CSF
规格： 50ug/支
产品描述
TGF-β family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis.As implied by their name, BMPs initiate, promote, and regulate the development, growth, and remodeling of boneand cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling,and maintenance of a variety of other tissues and organs. BMP-7, also known as osteogenic protein-1 or OP-1, is a potentbone inducing agent, which in the presence of an appropriate osteoconductive carrier (e.g. collagen sponge or synthetichydroxyapatite) can be used in the treatment of bone defects.A bone-graft substitute, called OP-1TM implant, made of recombinant human BMP-7 associated with bovine bone-derivedcollagen, has recently been approved by the FDA as a device for treating critical-size bone fractures.The potential use of BMP-7 in dental reconstructive surgeries is currently under investigation.Recombinant Human BMP-7 is a 28.8 kDa homodimeric glycoprotein consisting of two 117 amino acid subunits, whichcorrespond to amino acid residues 315 to 431 of the full-length BMP-7 precursor.